Polycystic ovary syndrome (PCOS) is a heterogeneous syndrome of reproductive and metabolic derangements. The combination
of anovulation and hyperandrogenism signifies the classic form of PCOS which displays the adverse metabolic phenotype of the
syndrome. This phenotype includes visceral obesity and insulin resistance as well as a constellation of other traditional cardiovascular
risk factors, mainly low grade inflammation, disturbances of glucose metabolism and dyslipidemia. The resultant increased risk for cardiovascular
disease may affect not only obese but also lean women with classic PCOS. The mechanisms underlying the increased cardiovascular
risk in the context of PCOS may include not only metabolic aberrations, but also hormonal factors, in particular hyperandrogenemia.
However, the consequences in terms of CV morbidity remain questionable due to the difficulties in conducting long-term, prospective
studies aimed at identifying potential late-arriving clinical outcomes.
Keywords: PCOS, hyperandrogenism, cardiovascular, metabolism, inflammation.
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