Mitochondrial Dysfunction and Oxidative Stress in Insulin Resistance

Author(s): Milagros Rocha, Susana Rovira-Llopis, Celia Banuls, Lorena Bellod, Rosa Falcon, Raquel Castello, Carlos Morillas, Jose R. Herance, Antonio Hernandez-Mijares, Victor M. Victor.

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 32 , 2013

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Abstract:

Evidence is mounting of the involvement of mitochondrial dysfunction in insulin resistance, diabetes and associated complications. This review aims to provide an overview of the effects of insulin resistance on mitochondrial function in several tissues. We consider the pathogenesis of insulin resistance from a mitochondrial perspective and contemplate potential beneficial effects of strategies aimed at modulating mitochondrial function in insulin resistance, including insulin and insulin-sensitizing drugs, antioxidants, and selectively targeting antioxidants to mitochondria.

Keywords: Insulin resistance, mitochondria, oxidative stress, antioxidants.

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Article Details

VOLUME: 19
ISSUE: 32
Year: 2013
Page: [5730 - 5741]
Pages: 12
DOI: 10.2174/13816128113199990373
Price: $58

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