Evidence is mounting of the involvement of mitochondrial dysfunction in insulin resistance, diabetes and associated complications.
This review aims to provide an overview of the effects of insulin resistance on mitochondrial function in several tissues. We consider
the pathogenesis of insulin resistance from a mitochondrial perspective and contemplate potential beneficial effects of strategies
aimed at modulating mitochondrial function in insulin resistance, including insulin and insulin-sensitizing drugs, antioxidants, and selectively
targeting antioxidants to mitochondria.
Keywords: Insulin resistance, mitochondria, oxidative stress, antioxidants.
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