Cardiovascular disease (CVD) is one of the major lifestyle associated disorders and leading causes of death worldwide. The
incidence of CVD in diabetic patients has increased up to 3 folds and it became the major risk for diabetes associated morbidity and mortality.
Insulin resistance and oxidative stress both play a central role in the pathogenesis and progression of diabetes. The high prevalence
of CVD among diabetic patients suggests the role of insulin resistance and oxidative stress in developing cardiovascular complications.
Finding molecular mechanisms which could control both insulin resistance and oxidative stress would be more efficacious in improving
the cardiovascular complications. Recent literatures show that an epigenetic mechanism could control or regulate the cardiovascular
complications in diabetes. Sirtuins, a group of enzymes, modulate epigenetic changes by deacetylating histone and non-histone proteins.
These enzymes are distributed in different cell organelles and are found to regulate different biological processes. Recent findings
showed that sirtuins modulate different important proteins related to insulin signaling pathway and oxidative stress. This review summarizes
how sirtuins could affect the insulin resistance and oxidative stress pathways in cardiovascular system and thus attenuate the cardiovascular
complications. Understanding the role of sirtuins in insulin resistance and oxidative stress will increase the prospects for controlling
or preventing cardiovascular complications in the future.
Keywords: Sirtuins, SIRT, insulin resistance, acetylation, mitochondria, oxidative stress, cardiovascular complications, diabetes.
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