Synthesis of Methylenebisamides by TFA-Promoted Reactions of Nitriles and DMSO

Author(s): Lingxia Pan, Lin Huang, Chunsong Xie.

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 10 , 2013

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Abstract:

Under TFA promoted conditions, aryl and 2-pyridyl nitriles can react with DMSO, affording methylenebisamides in moderate to good yields. While the electron-donating groups give good yields, the electron-withdrawing groups provide lower yields.

Keywords: Methylenebisamide, nitrile, DMSO.

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Article Details

VOLUME: 10
ISSUE: 10
Year: 2013
Page: [770 - 773]
Pages: 4
DOI: 10.2174/15701786113109990049
Price: $65

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