Objectives. To review the role of Wnt pathways in the neurodevelopment of schizophrenia.
Methods: Systematic PubMed search, using as keywords all the terms related to the Wnt pathways and crossing them with
each of the following areas: normal neurodevelopment and physiology, neurodevelopmental theory of schizophrenia,
schizophrenia, and antipsychotic drug action.
Results: Neurodevelopmental, behavioural, genetic, and psychopharmacological data point to the possible involvement of
Wnt systems, especially the canonical pathway, in the pathophysiology of schizophrenia and in the mechanism of
antipsychotic drug action. The molecules most consistently found to be associated with abnormalities or in antipsychotic
drug action are Akt1, glycogen synthase kinase3beta, and beta-catenin. However, the extent to which they contribute to
the pathophysiology of schizophrenia or to antipsychotic action remains to be established.
Conclusions: The study of the involvement of Wnt pathway abnormalities in schizophrenia may help in understanding this
multifaceted clinical entity; the development of Wnt-related pharmacological targets must await the collection of more data.