Abstract
Nociceptive primary afferents release glutamate, activating postsynaptic glutamate receptors on spinal cord dorsal horn neurons. Glutamate receptors, both ionotropic and metabotropic, are also expressed on presynaptic terminals, where they regulate neurotransmitter release. During the last two decades, a wide number of studies have characterized the properties of presynaptic glutamatergic receptors, particularly those expressed on primary afferent fibers. This review describes the subunit composition, distribution and function of presynaptic glutamate ionotropic (AMPA, NMDA, kainate) and metabotropic receptors expressed in rodent spinal cord dorsal horn. The role of presynaptic receptors in modulating nociceptive information in experimental models of acute and chronic pain will be also discussed.
Keywords: Spinal cord, pain, glutamate, presynaptic modulation, primary afferent fiber, primary afferent depolarization.
Current Neuropharmacology
Title:Role of Presynaptic Glutamate Receptors in Pain Transmission at the Spinal Cord Level
Volume: 11 Issue: 5
Author(s): Rita Bardoni
Affiliation:
Keywords: Spinal cord, pain, glutamate, presynaptic modulation, primary afferent fiber, primary afferent depolarization.
Abstract: Nociceptive primary afferents release glutamate, activating postsynaptic glutamate receptors on spinal cord dorsal horn neurons. Glutamate receptors, both ionotropic and metabotropic, are also expressed on presynaptic terminals, where they regulate neurotransmitter release. During the last two decades, a wide number of studies have characterized the properties of presynaptic glutamatergic receptors, particularly those expressed on primary afferent fibers. This review describes the subunit composition, distribution and function of presynaptic glutamate ionotropic (AMPA, NMDA, kainate) and metabotropic receptors expressed in rodent spinal cord dorsal horn. The role of presynaptic receptors in modulating nociceptive information in experimental models of acute and chronic pain will be also discussed.
Export Options
About this article
Cite this article as:
Bardoni Rita, Role of Presynaptic Glutamate Receptors in Pain Transmission at the Spinal Cord Level, Current Neuropharmacology 2013; 11 (5) . https://dx.doi.org/10.2174/1570159X11311050002
DOI https://dx.doi.org/10.2174/1570159X11311050002 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Biological Therapies in Osteoarthritis
Current Pharmaceutical Design Folate Based Radiopharmaceuticals for Imaging and Therapy of Cancer and Inflammation
Current Pharmaceutical Design Synthesis of Asymmetric 1-Thiocarbamoyl Pyrazoles as Potent Anti- Colon Cancer, Antioxidant and Anti-Inflammatory Agent
Anti-Cancer Agents in Medicinal Chemistry Commentary Research Highlights (Amyloid β-Peptide and Alzheimer’s Disease: It’s All the RAGE)
CNS & Neurological Disorders - Drug Targets Traditional and Alternative Therapies for Refractory Angina
Current Pharmaceutical Design Mechanisms and Treatment of Neuropathic Pain
Central Nervous System Agents in Medicinal Chemistry “Reports of an Addiction”: Therapeutic Intervention with a Young Adult with Cannabis Dependence
Adolescent Psychiatry Toll-Like Receptors in Alzheimer's Disease: A Therapeutic Perspective
CNS & Neurological Disorders - Drug Targets Boronate Can Be the Fluorogenic Switch for the Detection of Hydrogen Peroxide
Current Medicinal Chemistry Sweet and Sour - Oxidative and Carbonyl Stress in Neurological Disorders
CNS & Neurological Disorders - Drug Targets Polyunsaturated Fatty Acids and their Metabolites in Neural Development and Implications for Psychiatric Disorders
Current Psychopharmacology Novel Strategies in Drug Discovery of the Calcium-Sensing Receptor Based on Biased Signaling
Current Drug Targets RAGE: A Multi-Ligand Receptor Unveiling Novel Insights in Health and Disease
Current Medicinal Chemistry Molecular Mechanisms and Therapeutic Application of NSAIDs and Derived Compounds in Alzheimers Disease
Current Alzheimer Research Editorial [Hot Topic: Pharmacotherapies for the Treatment of Alcohol Abuse and Dependence (Guest Editors: Feng C. Zhou and Richard L. Bell)]
Recent Patents on CNS Drug Discovery (Discontinued) D-Serine Regulation: A Possible Therapeutic Approach for Central Nervous Diseases and Chronic Pain
Mini-Reviews in Medicinal Chemistry Different Levels of Activity in the Left Intraparietal Sulcus Triggered by Lasting and Unlasting Cues in the Posner Task
Neuroscience and Biomedical Engineering (Discontinued) An Overview of Bioinformatics Methods for Analyzing Autism Spectrum Disorders
Current Pharmaceutical Design The Potential of Caffeine for Functional Modification from Cortical Synapses to Neuron Networks in the Brain
Current Neuropharmacology Fungal Bioactive Compounds in Pharmaceutical Research and Development
Current Bioactive Compounds