T3 and Cardiac Myocyte Cell: A Theoretical Model
Tsatsaris Athanasios, Baldoukas Antonios, Loumousiotis Antonios, Koukounaris Eustathios, Giota Maria and Perrea Despina
Affiliation: Laboratory of Experimental Surgery and Surgical Research University of Athens, Greece.
In the last decades, the outstanding role of Thyroid gland in regulating both physiological and pathological operation
of cardiovascular system has been acknowledged worldwide. Three main domains of Thyroid function, that is to
say, euthyroidism -hyperthyroidism-hypothyroidism, have a direct impact on cardiac response through a variety of
mechanisms. Cellular pathways mediate in cardiac contractility, cardiac output, cardiac rhythm, arterial blood pressure
and peripheral vessel resistance. Particular biochemical algorithms exist not only between Thyroid hormones’ serum
concentration and thyroid gland but also between the hormones’ serum level and heart muscle genes. These biochemical
pathways primarily regulate the appropriate secretion of levothyroxine (T4) and triiodothyronine(T3) via Thyroid-
Stimulating-Hormone(TSH) pituitary system, and secondly adjust the cardiac function. In this study, a mathematic model
has been developed describing significant aspects of positive or negative feedback mechanisms of THYRO-CARDIAC
(THY-CAR) system along with potential applications of novel up-to-date patents in this area of research.
Keywords: Cardiovascular disease, cellular mechanism, mathematic model, thyroid hormone, thiidothyronine.
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