Abstract
The involvement of microRNAs in human cancer is now well established. A few miRNAs function as oncogenes and many others display tumor suppressor activities. Several studies in the past few years have highlighted and reinforced a role for miR-203 as a tumor suppressor microRNA. This collection of in vitro studies give an initial and stimulating look into the many different means by which miR-203 can inhibit the various pathways involved in cell transformation and metastasis. Of special relevance is the ability of miR-203 to prevent proliferation of progenitor cells as well the epithelial-to-mesenchymal transition frequently associated with cancer progression and metastasis. Further more, the breadth of cancer types examined in these studies implicates miR-203 as a potential tumor suppressor gene whose reexpression or re-introduction into malignant cells could, by nature of its inherent pleiotropic effects as a miRNA, represent an important therapeutic tool used to combat a multitude of human cancers.
Keywords: Cell proliferation, microRNA, oncogenesis, progenitor cell, stemness, tumor suppression.
MicroRNA
Title:MicroRNA-203: Tumor Suppression and Beyond
Volume: 2 Issue: 2
Author(s): Carlos I. Michel and Marcos Malumbres
Affiliation:
Keywords: Cell proliferation, microRNA, oncogenesis, progenitor cell, stemness, tumor suppression.
Abstract: The involvement of microRNAs in human cancer is now well established. A few miRNAs function as oncogenes and many others display tumor suppressor activities. Several studies in the past few years have highlighted and reinforced a role for miR-203 as a tumor suppressor microRNA. This collection of in vitro studies give an initial and stimulating look into the many different means by which miR-203 can inhibit the various pathways involved in cell transformation and metastasis. Of special relevance is the ability of miR-203 to prevent proliferation of progenitor cells as well the epithelial-to-mesenchymal transition frequently associated with cancer progression and metastasis. Further more, the breadth of cancer types examined in these studies implicates miR-203 as a potential tumor suppressor gene whose reexpression or re-introduction into malignant cells could, by nature of its inherent pleiotropic effects as a miRNA, represent an important therapeutic tool used to combat a multitude of human cancers.
Export Options
About this article
Cite this article as:
Michel I. Carlos and Malumbres Marcos, MicroRNA-203: Tumor Suppression and Beyond, MicroRNA 2013; 2 (2) . https://dx.doi.org/10.2174/22115366113029990016
DOI https://dx.doi.org/10.2174/22115366113029990016 |
Print ISSN 2211-5366 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5374 |
Call for Papers in Thematic Issues
Modulatory Roles of Non-coding RNAs in cancer therapy
This thematic issue aims to elucidate the most recent research on ncRNAs in CRCs and discuss the importance and difficulties that may arise in applying this tool on a regular clinical basis.read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Yin and Yang of Polyphenols in Cancer Prevention: A Short Review
Anti-Cancer Agents in Medicinal Chemistry Monoclonal Antibodies in the Management of Solid Tumors
Current Topics in Medicinal Chemistry Microtubules in Apoptosis Induction: Are They Necessary?
Current Cancer Drug Targets Viral and Non-Viral Approaches for Transient Delivery of mRNA and Proteins
Current Gene Therapy Metabolomic Heterogeneity of Urogenital Tract Cancers Analyzed by Complementary Chromatographic Techniques Coupled with Mass Spectrometry
Current Medicinal Chemistry Nanocarriers for Gene Delivery - Polymer Structure, Targeting Ligands and Controlled-Release Devices
Current Nanoscience Heat Shock Proteins (HSPs): A Novel Target for Cancer Metastasis Prevention
Current Drug Targets Application of MALDI/SELDI Mass Spectrometry to Cancer Biomarker Discovery and Validation
Current Proteomics Oxidative Stress and Antioxidants in Carcinogenesis and Integrative Therapy of Cancer
Current Pharmaceutical Design Controlled Releases of FGF-2 and Paclitaxel from Chitosan Hydrogels and their Subsequent Effects on Wound Repair, Angiogenesis, and Tumor Growth
Current Drug Delivery Lipid-based Nanocarriers As An Alternative for Oral Delivery of Poorly Water- Soluble Drugs: Peroral and Mucosal Routes
Current Medicinal Chemistry Drug Acyl Glucuronides: Reactivity and Analytical Implication
Current Pharmaceutical Analysis Inhibition of Bacterial Carbonic Anhydrases and Zinc Proteases: From Orphan Targets to Innovative New Antibiotic Drugs
Current Medicinal Chemistry Identification of KEY lncRNAs and mRNAs Associated with Oral Squamous Cell Carcinoma Progression
Current Bioinformatics Phage Display Applications for Molecular Imaging
Current Pharmaceutical Biotechnology Targeting the p53-Family in Cancer and Chemosensitivity: Triple Threat
Current Drug Targets Radiosensitization of Prostate Cancer by Soy Isoflavones
Current Cancer Drug Targets The Epithelial-Mesenchymal Transition and Cancer Stem Cells: Functional and Mechanistic Links
Current Pharmaceutical Design Long Noncoding RNA MALAT1: Insights into its Biogenesis and Implications in Human Disease
Current Pharmaceutical Design The ErbB Receptors and their Ligands in Cancer: An Overview
Current Drug Targets