MicroRNA-203: Tumor Suppression and Beyond
Carlos I. Michel and Marcos Malumbres
Affiliation: Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, E-28029 Madrid, Spain.
Keywords: Cell proliferation, microRNA, oncogenesis, progenitor cell, stemness, tumor suppression.
The involvement of microRNAs in human cancer is now well established. A few miRNAs function as oncogenes
and many others display tumor suppressor activities. Several studies in the past few years have highlighted and reinforced
a role for miR-203 as a tumor suppressor microRNA. This collection of in vitro studies give an initial and stimulating
look into the many different means by which miR-203 can inhibit the various pathways involved in cell transformation
and metastasis. Of special relevance is the ability of miR-203 to prevent proliferation of progenitor cells as well the
epithelial-to-mesenchymal transition frequently associated with cancer progression and metastasis. Further more, the
breadth of cancer types examined in these studies implicates miR-203 as a potential tumor suppressor gene whose reexpression
or re-introduction into malignant cells could, by nature of its inherent pleiotropic effects as a miRNA, represent
an important therapeutic tool used to combat a multitude of human cancers.
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