Non Coding RNA in Muscle Differentiation and Disease
Mariangela Morlando, Alessandro Rosa, Elisa Caffarelli, Alessandro Fatica and Irene Bozzoni
Affiliation: Dept. of Biology and Biotechnology "Charles Darwin”, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome – Italy.
Non coding RNAs have provided in the last decades a very exciting research field with the discovery that a
largely unexplored fraction of our genome encodes for RNA without protein coding activity. Here we revise the current
knowledge of how non coding RNAs impact on muscle differentiation and homeostasis in normal and disease conditions
and how they can provide powerful tools for therapeutic interventions and disease diagnosis. Moreover, we discuss new
insights into additional mechanisms of post-transcriptional regulation involving a new class of long non coding RNAs
shown to impact on the distribution of microRNA molecules on their mRNA targets.
Keywords: Duchenne Muscular Dystrophy, dystrophin, lncRNA, microRNA, muscle differentiation, ncRNA.
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