Protein tyrosine phosphatase 1B (PTP1B) is a prototype non receptor cytoplasmic PTPase enzyme that has
been implicated in regulation of insulin and leptin signaling pathways. Studies on PTP1B knockout mice and PTP1B antisense
treated mice suggested that inhibition of PTP1B would be an effective strategy for the treatment of type II diabetes
and obesity. Here we report the X-ray structure of PTP1B in complex with compound IN1834-146C (PDB ID 4I8N). The
crystals belong to P3121 space group with cell dimensions (a = b = 87.89 Å, c = 103.68 Å) diffracted to 2.5 Å. The crystal
structure contained one molecule of protein in the asymmetric unit and was solved by molecular replacement method. The
compound engages both catalytic site and allosteric sites of PTP1B protein. We described the molecular interaction of the
compound with the active site residues of PTP1B in this crystal structure report.
Keywords: Protein tyrosine phosphatases (PTP1B), T cell PTP (TCPTP) and X-Ray Crystallography.
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