Induced Pluripotent Stem Cells for the Treatment of Stroke: The Potential and the Pitfalls
Cindi M. Morshead.
The extraordinary discovery of induced pluripotent stem cells (iPSCs) has led to the very real possibility that
patient-specific cell therapy can be realized. The potential to develop cell replacement therapies outside the ethical and legal
limitations, has initiated a new era of hope for regenerative strategies to treat human neurological disease including
stroke. In this article, we will review and compare the current approaches to derive iPSCs from different somatic cells, and
the induction into neuronal phenotypes, considering the advantages and disadvantages to the methodologies of derivation.
We will highlight the work relating to the use of iPSC-based therapies in models of stroke and their potential use in clinical
trials. Finally, we will consider future directions and areas of exploration which may promote the realization of iPSC-based
cell replacement strategies for the treatment of stroke.
Keywords: Animal models, induced pluripotent stem cells, neural progenitor cells, stroke.
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