7,9,12b-Triazabenzo[a]aceanthrylen-8-one, the First Representative of a Novel Pentacyclic Ring System and its Biological Activities

Author(s): Andreas Puzik, Franz Bracher.

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 8 , 2013

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Abstract:

The first entry to the 7,9,12b-triazabenzo[a]aceanthrylene ring system has been accomplished starting from readily accessible 1-(2-bromoacetyl)-β-carboline via 5-aminocanthin-4-one in four steps. The 8-oxo derivative, which can be considered as an annulated diazaacridone, exhibits significant antimicrobial properties.

Keywords: Canthin-4-one, β-Carboline, Diazaacridone, Skraup synthesis, Phthalimide, Antibacterial activity, Antifungal activity.

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Article Details

VOLUME: 10
ISSUE: 8
Year: 2013
Page: [568 - 572]
Pages: 5
DOI: 10.2174/1570178611310080006
Price: $65

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