Synthesis of 1,4-dihydropyridine Derivatives via One Pot Multicomponent Condensation in Water

Author(s): Arash Ghorbani-Choghamarani, Masoomeh Norouzi.

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 8 , 2013

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A facile and efficient one-pot preparation of a new series of 1,4-dihydropyridines has been reported via a threecomponent reaction of nano aluminum nitride, aromatic aldehydes and benzyl-3-oxobutanoate or 2-methoxyethyl-3- oxobutanoateat 80 °C in water. Using this methodology, Hantzsch1,4-dihydropyridine derivatives were synthesized in a simple pathway without the use of a catalyst or an organic solvent.

Keywords: 1, 4-Dihydropyridine, Hantzsch reaction, One-pot condensation, Multicomponent, Aluminum nitride.

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Article Details

Year: 2013
Page: [562 - 567]
Pages: 6
DOI: 10.2174/15701786113109990012
Price: $65

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