A simple and efficient indium(III)-catalyzed sp3-sp C-C bond formation reaction via direct coupling of alcohols
with terminal alkynes has been developed under mild conditions without any ligand, base or additive, in which both of
aromatic and aliphatic alkynes and various alcohols such as benzylic, allylic and propargylic alcohols can be tolerated.
This simple reaction system provides an attractive approach to a large number of internal alkynes in moderate to good
yields, and only generates H2O as the side product.
Keywords: sp3-sp C-C bond, alkynes, alcohols, indium(III) salts, catalytic synthesis, coupling reaction.
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