Synthesis of Allosamidin Analogue Di-N-acetyl-β-chitobiosyl N-Glycoaminooxazoline

Author(s): Gangliang Huang, Shuangquan Shu, Fei Cheng.

Journal Name: Letters in Drug Design & Discovery

Volume 10 , Issue 8 , 2013

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Abstract:

The solid-phase synthesis of di-N-acetyl-β-chitobiosyl N-glycoaminooxazoline 2 was studied. The synthesis was gone along using the N-benzyloxycarbonyl (Cbz) protected trichloroacetimidates 11 and 13 as donors, polystyrene as support, and o-nitrobenzyl ether tether as linker. The compound 2 was high-efficiently offered by three glycosylations, catalytic hydrogenolysis, acetylation, deacetylation, and photolysis, respectively.

Keywords: Di-N-acetyl-β-chitobiosyl N-glycoaminooxazoline, Solid-phase synthesis, Glycosylation, Analogue.

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Article Details

VOLUME: 10
ISSUE: 8
Year: 2013
Page: [738 - 740]
Pages: 3
DOI: 10.2174/15701808113109990008
Price: $58

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