Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

Back

Synthesis of Allosamidin Analogue Di-N-acetyl-β-chitobiosyl N-Glycoaminooxazoline

Author(s): Gangliang Huang, Shuangquan Shu, Fei Cheng.

Abstract:

The solid-phase synthesis of di-N-acetyl-β-chitobiosyl N-glycoaminooxazoline 2 was studied. The synthesis was gone along using the N-benzyloxycarbonyl (Cbz) protected trichloroacetimidates 11 and 13 as donors, polystyrene as support, and o-nitrobenzyl ether tether as linker. The compound 2 was high-efficiently offered by three glycosylations, catalytic hydrogenolysis, acetylation, deacetylation, and photolysis, respectively.

Keywords: Di-N-acetyl-β-chitobiosyl N-glycoaminooxazoline, Solid-phase synthesis, Glycosylation, Analogue.

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 10
ISSUE: 8
Year: 2013
Page: [738 - 740]
Pages: 3
DOI: 10.2174/15701808113109990008
Price: $58