Abstract
A new combination of reagent (ZnCl2/TBAB) system has been developed for the preparation of dihydropyrimidinones by using aldehyde, acetoacetic ester and urea or thiourea. These improved reaction condition allow the preparation of a wide variety of substituted dihydropyrimidinones in high yields and purity under mild reaction conditions. Some of the dihydropyrimidinones were showed moderate in vitro cytotoxic activity against U937, Colo205, A549 and THP-1 human cancer cell lines. Some of the compounds have been found promising anticancer activity when compared standard drug etoposide.
Keywords: Biginelli reaction, ZnCl2/TBAB catalyst, Dihydropyrimidinones, One pot synthesis, MTT assay, Cytotoxicity.
Letters in Drug Design & Discovery
Title:Synthesis and Cytotoxic Evaluation for Some New Dihydropyrimidinone Derivatives for Anticancer Activity
Volume: 10 Issue: 8
Author(s): Onteddu. Surendranatha Reddy, Ch. Venkata Suryanarayana, N. Sharmila, G. V. Ramana, V. Anuradha and B. Hari Babu
Affiliation:
Keywords: Biginelli reaction, ZnCl2/TBAB catalyst, Dihydropyrimidinones, One pot synthesis, MTT assay, Cytotoxicity.
Abstract: A new combination of reagent (ZnCl2/TBAB) system has been developed for the preparation of dihydropyrimidinones by using aldehyde, acetoacetic ester and urea or thiourea. These improved reaction condition allow the preparation of a wide variety of substituted dihydropyrimidinones in high yields and purity under mild reaction conditions. Some of the dihydropyrimidinones were showed moderate in vitro cytotoxic activity against U937, Colo205, A549 and THP-1 human cancer cell lines. Some of the compounds have been found promising anticancer activity when compared standard drug etoposide.
Export Options
About this article
Cite this article as:
Reddy Surendranatha Onteddu., Suryanarayana Venkata Ch., Sharmila N., Ramana V. G., Anuradha V. and Babu Hari B., Synthesis and Cytotoxic Evaluation for Some New Dihydropyrimidinone Derivatives for Anticancer Activity, Letters in Drug Design & Discovery 2013; 10 (8) . https://dx.doi.org/10.2174/15701808113109990007
DOI https://dx.doi.org/10.2174/15701808113109990007 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
CD40L - A Multipotent Molecule for Tumor Therapy
Endocrine, Metabolic & Immune Disorders - Drug Targets Synthesis of resveratrol acrylamides derivatives and biological evaluation of their anti-proliferative effect on cancer cell lines
Letters in Drug Design & Discovery A New Therapeutic Era in GCB and ABC Diffuse Large B-cell Lymphom a Molecular Subtypes: A Cell of Origin-Driven Review
Current Cancer Drug Targets Boronic Acid-based Enzyme Inhibitors: A Review of Recent Progress
Current Medicinal Chemistry Therapeutic Potential of Drugs Targeting Pathophysiology of Intracerebral Hemorrhage: From Animal Models to Clinical Applications
Current Pharmaceutical Design The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases
Mini-Reviews in Medicinal Chemistry How is Gene Transfection Able to Improve Current Chemotherapy? The Role of Combined Therapy in Cancer Treatment
Current Medicinal Chemistry Methotrexate-Induced Pneumonitis: Heterogeneity of Bronchoalveolar Lavage and Differences between Cancer and Rheumatoid Arthritis
Inflammation & Allergy - Drug Targets (Discontinued) Endoradiotherapy with Peptides - Status and Future Development
Current Medicinal Chemistry Biologic Therapies in Primary Sjögren's Syndrome
Current Pharmaceutical Biotechnology Role of Antimicrobial Peptides Expressed by Host Cells Upon Infection by Helicobacter pylori
Protein & Peptide Letters Predicting Toxicity: Biomarkers and the Value of the Patient's Opinion
Current Pharmaceutical Design Statins-Mediated Inhibition of Rho GTPases as a Potential Tool in Anti-Tumor Therapy
Mini-Reviews in Medicinal Chemistry MicroRNAs in Human Virus Genomes: Helping Hands for Viral Infection
MicroRNA Peptide-Receptor Ligands and Multivalent Approach
Anti-Cancer Agents in Medicinal Chemistry Recent Advancement in Natural Hyaluronidase Inhibitors
Current Topics in Medicinal Chemistry Mechanisms of Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and New Therapeutic Perspectives in Non Small Cell Lung Cancer
Current Drug Targets Small Molecules ATP-Competitive Inhibitors of FLT3: A Chemical Overview
Current Medicinal Chemistry Clinical Update: Treatment of Glioblastoma Multiforme with Radiolabeled Antibodies that Target Tumor Necrosis
Current Cancer Therapy Reviews Inhibitors of Lactate Dehydrogenase Isoforms and their Therapeutic Potentials
Current Medicinal Chemistry