Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis and Cytotoxic Evaluation for Some New Dihydropyrimidinone Derivatives for Anticancer Activity

Author(s): Onteddu. Surendranatha Reddy, Ch. Venkata Suryanarayana, N. Sharmila, G. V. Ramana, V. Anuradha, B. Hari Babu.


A new combination of reagent (ZnCl2/TBAB) system has been developed for the preparation of dihydropyrimidinones by using aldehyde, acetoacetic ester and urea or thiourea. These improved reaction condition allow the preparation of a wide variety of substituted dihydropyrimidinones in high yields and purity under mild reaction conditions. Some of the dihydropyrimidinones were showed moderate in vitro cytotoxic activity against U937, Colo205, A549 and THP-1 human cancer cell lines. Some of the compounds have been found promising anticancer activity when compared standard drug etoposide.

Keywords: Biginelli reaction, ZnCl2/TBAB catalyst, Dihydropyrimidinones, One pot synthesis, MTT assay, Cytotoxicity.

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Article Details

Year: 2013
Page: [699 - 705]
Pages: 7
DOI: 10.2174/15701808113109990007
Price: $58