Synthesis and Biological Evaluation of 1, 3-Dihydroxyxanthone Mannich Base Derivatives as Potential Antitumor Agents

Title:Synthesis and Biological Evaluation of 1, 3-Dihydroxyxanthone Mannich Base Derivatives as Potential Antitumor Agents

Volume: 10 Issue: 8

Author(s): Wenli Lan, Jingchen Wei, Jiangke Qin, Zhengmin Yang, Guifa Su and Zhikai Dai

Affiliation:

Keywords: Xanthone derivatives, Synthesis, Mannich bases, Antitumor activity, Structure-activity relationships, MTT assay.

Abstract: A novel series of Mannich bases of 1, 3-dihydroxyxanthone derivatives were designed and synthesized. The chemical structures of the compounds were characterized by IR, MS and NMR spectra. Their in vitro toxicities on six tumor cell lines including NCI-H460 (lung cancer), TCA-8113 (tongue squamous cell carcinomas), BEL-7402 (liver cancer), HepG2 (hepatocarcinoma), SGC-7901 (gastric carcinoma) and T24 (urinary bladder carcinoma) were studied through MTT assay. The results showed that most of the compounds displayed mild to good inhibitory activities on the cancer cell lines. Some preliminary structure-activity relationships were also discussed.

Cite this article as:

Lan Wenli, Wei Jingchen, Qin Jiangke, Yang Zhengmin, Su Guifa and Dai Zhikai, Synthesis and Biological Evaluation of 1, 3-Dihydroxyxanthone Mannich Base Derivatives as Potential Antitumor Agents, Letters in Drug Design & Discovery 2013; 10 (8) . https://dx.doi.org/10.2174/15701808113100890029