Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis and Biological Evaluation of 1, 3-Dihydroxyxanthone Mannich Base Derivatives as Potential Antitumor Agents

Author(s): Wenli Lan, Jingchen Wei, Jiangke Qin, Zhengmin Yang, Guifa Su, Zhikai Dai.


A novel series of Mannich bases of 1, 3-dihydroxyxanthone derivatives were designed and synthesized. The chemical structures of the compounds were characterized by IR, MS and NMR spectra. Their in vitro toxicities on six tumor cell lines including NCI-H460 (lung cancer), TCA-8113 (tongue squamous cell carcinomas), BEL-7402 (liver cancer), HepG2 (hepatocarcinoma), SGC-7901 (gastric carcinoma) and T24 (urinary bladder carcinoma) were studied through MTT assay. The results showed that most of the compounds displayed mild to good inhibitory activities on the cancer cell lines. Some preliminary structure-activity relationships were also discussed.

Keywords: Xanthone derivatives, Synthesis, Mannich bases, Antitumor activity, Structure-activity relationships, MTT assay.

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Article Details

Year: 2013
Page: [689 - 698]
Pages: 10
DOI: 10.2174/15701808113100890029
Price: $58