Development and in vitro Evaluation of Diclofenac Sodium Loaded Mucoadhesive Microsphere with Natural Gum for Sustained Delivery

Author(s): Md. Lutful Amin, Tasbira Jesmeen, Kumar Bishwajit Sutradhar, Md. Abdul Mannan.

Journal Name: Current Drug Delivery

Volume 10 , Issue 6 , 2013

Become EABM
Become Reviewer

Abstract:

The objective of this study was to develop and evaluate mucoadhesive microsphere of diclofenac sodium with natural gums for sustained delivery. Guar gum and tragacanth were used along with sodium alginate as mucoadhesive polymers. Microspheres were formulated using orifice-ionic gelation method. Particle size, surface morphology, swelling study and drug entrapment efficiency of the prepared microspheres were determined. In vitro evaluation was carried out comprising of mucoadhesion and drug release study. The prepared microspheres were discrete and free flowing. Sodium alginate and natural gum, at a ratio of 1:0.25, showed good mucoadhesive property and they had high drug entrapment efficiencies. They also exhibited the best rate retarding effect among all the formulations. Drug entrapment efficiency of all the microspheres ranged from 80.42% to 91.67%. An inverse relationship was found between extent of crosslinking and drug release rate. Release rate was slow and extended in case of the formulations of 1:0.25 ratio (F1 and F3), releasing 68.36% and 70.56% drug respectively after 8 hours. Tragacanth-containing microspheres of F1 showed superiority over other formulations, with best mucoadhesive and rate retarding profile. The correlation value (r2) indicated that the drug release of all the formulations followed Higuchi’s model. Overall, the results indicated that mucoadhesive microspheres containing natural gum can be promising in terms of prolonged delivery with good mucoadhesive action, targeting the absorption site to thrive oral drug delivery.

Keywords: Crosslinked microsphere, diclofenac sodium, sustained delivery, mucoadhesive microsphere, natural gum, orificeionic gelation method.

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 10
ISSUE: 6
Year: 2013
Page: [765 - 770]
Pages: 6
DOI: 10.2174/15672018113109990054
Price: $58

Article Metrics

PDF: 14