The Critical Roles of HSC70 in Physiological and Pathological Processes

Author(s): Yi Liao, Liling Tang.

Journal Name: Current Pharmaceutical Design

Volume 20 , Issue 1 , 2014

Abstract:

The heat stress cognate 70 is one of the major cytoplasmic chaperones to supply a multitude of the housekeeping chaperoning functions. In addition to its high constitutive expression, recent studies have demonstrated that it is also inducible. Another exciting discovery is that the regulation of heat stress cognate 70 plays important roles in the aging process and aging-related diseases. Besides the chaperone functions, heat stress cognate 70 is involved in the inflammatory signal pathways via extracellular interaction with TLR2/TLR4. Furthermore, studies have validated the ability of extracellular heat stress cognate 70 to regulate cancer cell proliferation and sperm storage. The discovery of heat stress cognate 70 secretion, in normal and cancer cells undergoing stress, presents novel therapeutic strategies.

Keywords: Aging, expression, HSC70, signaling, spermatogenesis, stressors.

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Article Details

VOLUME: 20
ISSUE: 1
Year: 2014
Page: [101 - 107]
Pages: 7
DOI: 10.2174/13816128113199990585
Price: $58

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