HR-MAS NMR Spectroscopy: A Practical Guide for Natural Samples

Author(s): Hashim Farooq, Denis Courtier-Murias, Ronald Soong, Wolfgang Bermel, William M. Kingery, André J. Simpson.

Journal Name:Current Organic Chemistry

Volume 17 , Issue 24 , 2013

Abstract:

High Resolution Magic Angle Spinning (HR-MAS) NMR spectroscopy is a versatile technique that provides high resolution NMR data on samples containing solutions, gels and swellable solids. In addition to providing structural information HR-MAS can also be used to investigate interfaces (for example organic structures at the solid-aqueous soil interface), processes such as swelling/ flocculation, kinetic transfer between gel/liquid phases, as well as conformation and molecular interactions in situ. As such, HRMAS has potential in a diversity of fields including organic, biological, environmental, and medical research. This manuscript focuses on the application of HR-MAS to intact natural samples. A range of 1D and 2D NMR experiments are reviewed and compared in terms of general performance on a range of samples. Therefore, this practical guide and review should be a useful reference and starting point for those wishing to apply HR-MAS NMR. While this article focuses on natural samples, common key 1D and 2D experiments are considered which may be of interest to readers with diverse research interests.

Keywords: 1D NMR, 2D NMR, Algae, High resolution magic angle spinning (HR-MAS), Natural samples, NMR, Soils, Worm tissue.

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Article Details

VOLUME: 17
ISSUE: 24
Year: 2013
Page: [3013 - 3031]
Pages: 19
DOI: 10.2174/13852728113179990126