Current Alzheimer Research

Debomoy K. Lahiri  
Department of Psychiatry, Indiana University School of Medicine
Neuroscience Research Center
Indianapolis, IN 46202


Translate in Chinese

Alzheimer’s Disease is Associated with Increased Risk of Osteoporosis: The Chongqing Aging Study

Author(s): Dong Liu, Huadong Zhou, Yong Tao, Jun Tan, Lin Chen, Haiyang Huang, Yang Chen, Yafei Li, Rui Zhou.


Objective: The aim of this study was to analyze the relationship between Alzheimer’s disease (AD) and a risk of osteoporosis in the elderly cohort of Chongqing, China.

Methods: A prospective study with 6 years of follow-up in 1802 patients aged 60– 75 was conducted from January 2007 to June 2013. Dual energy X-ray absorptiometry was utilized to evaluate bone mineral density (BMD). Their cognitive function was detected using the Chinese version of the Mini-Mental State Examination (MMSE) and a detection of the instrumental activities of daily living (ADL). Cox proportional hazards models were used to detect the association between AD and the risk of osteoporosis.

Results: After adjusting for age, female, AD, 25-hydroxyvitamine D (25(OH)D), smoking, drinking and stroke, AD (Hazard ratio, HR 2.48, 95%CI 1.66-2.94), age (HR 1.36, 95% CI 1.14-1.60), female (HR 1.39, 95% CI 1.17-1.65), 25(OH)D (HR1.34, 95%CI 1.11-1.59), current smoking (HR 1.27, 95%CI 1.22-1.43), daily drinking (HR 1.33, 95%CI 1.11-1.52) and stroke (HR 1.26, 95%CI 1.14-1.58) were associated with increased risk of osteoporosis. In osteoporosis fracture group, osteoporosis with AD was more common than osteoporosis with normal cognition function.

Conclusion: AD was associated with an increased risk of osteoporosis in the elderly cohort of Chongqing, China.

Keywords: Alzheimer’s disease, dementia, estrogen, fracture, hypercholesterolemia, osteoporosis.

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

Year: 2016
Page: [1165 - 1172]
Pages: 8
DOI: 10.2174/15672050113109990149
Price: $58