Current Alzheimer Research

Debomoy K. Lahiri  
Department of Psychiatry, Indiana University School of Medicine
Neuroscience Research Center
Indianapolis, IN 46202
USA

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Alzheimer’s Disease is Associated with Increased Risk of Osteoporosis: The Chongqing Aging Study

Author(s): Dong Liu, Huadong Zhou, Yong Tao, Jun Tan, Lin Chen, Haiyang Huang, Yang Chen, Yafei Li, Rui Zhou.

Abstract:

Objective: The aim of this study was to analyze the relationship between Alzheimer’s disease (AD) and a risk of osteoporosis in the elderly cohort of Chongqing, China.

Methods: A prospective study with 6 years of follow-up in 1802 patients aged 60– 75 was conducted from January 2007 to June 2013. Dual energy X-ray absorptiometry was utilized to evaluate bone mineral density (BMD). Their cognitive function was detected using the Chinese version of the Mini-Mental State Examination (MMSE) and a detection of the instrumental activities of daily living (ADL). Cox proportional hazards models were used to detect the association between AD and the risk of osteoporosis.

Results: After adjusting for age, female, AD, 25-hydroxyvitamine D (25(OH)D), smoking, drinking and stroke, AD (Hazard ratio, HR 2.48, 95%CI 1.66-2.94), age (HR 1.36, 95% CI 1.14-1.60), female (HR 1.39, 95% CI 1.17-1.65), 25(OH)D (HR1.34, 95%CI 1.11-1.59), current smoking (HR 1.27, 95%CI 1.22-1.43), daily drinking (HR 1.33, 95%CI 1.11-1.52) and stroke (HR 1.26, 95%CI 1.14-1.58) were associated with increased risk of osteoporosis. In osteoporosis fracture group, osteoporosis with AD was more common than osteoporosis with normal cognition function.

Conclusion: AD was associated with an increased risk of osteoporosis in the elderly cohort of Chongqing, China.

Keywords: Alzheimer’s disease, dementia, estrogen, fracture, hypercholesterolemia, osteoporosis.

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Article Details

VOLUME: 13
ISSUE: 10
Year: 2016
Page: [1165 - 1172]
Pages: 8
DOI: 10.2174/15672050113109990149
Price: $58