Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis of resveratrol acrylamides derivatives and biological evaluation of their anti-proliferative effect on cancer cell lines

Author(s): Ban-Feng Ruan, Si-Qi Wang, Xiao-Lin Ge, Ri-Sheng Yao.

Abstract:

A new series of resveratrol acrylamides amine derivatives was designed, synthesized, and evaluated for their anti-proliferative activity against three cancer cell lines including human chronic myelocytic leukemia cell K562, human hepatoma HuH-7 and human lung carcinoma A549. Most of the compounds showed superior activity against three cell lines when compared to parent resveratrol. C13 had the best anti-tumor activity against the HuH-7 cell line and its IC50 was 4.5 μmol/L; C16 had the best anti-tumor activity against the K562 cell line and its IC50 was 2.9 μmol/L; C18 had the best anti-tumor activity against the A549 cell line and its IC50 was 3.8 μmol/L. It could be seen that the activity of the aromatic amine derivatives was better than the fatty amine derivatives by analyzing the experimental data.

Keywords: Resveratrol, Acrylamides amine, Anti-proliferative effect, SynthesisResveratrol, Acrylamides amine, Anti-proliferative effect, Synthesis

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Article Details

VOLUME: 11
ISSUE: 1
Year: 2014
Page: [2 - 9]
Pages: 8
DOI: 10.2174/15701808113109990057