Augmenting the Xanthine Oxidase Inhibitory Activity of Febuxostat by its Structural Modification

Author(s): Kuruva Chandra Sekhar, Golla Madhava, Katla Venkata Ramana, CH. Rama Murthy, Chamarthi Naga Raju.

Journal Name: Letters in Drug Design & Discovery

Volume 11 , Issue 2 , 2014

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The carboxamide derivatives of Febuxostat were synthesized via the reaction of Febuxostat with various amines through by Schotten-Baumann reaction. All the synthesized compounds have been evaluated for their in vitro Xanthine Oxidase inhibitory activity. The present study reveals that most of carboxamides were acting as better XO inhibitors and play an important role in decreasing uricacid levels. Almost all the compounds surprisingly showed nearly 30% higher XO inhibition activities than the standard Allopurinol. 3h, 3k and 3l stand as the best among the synthesized compounds.

Keywords: Febuxostat carboxamide derivatives, Schotten-Baumann reaction, Xanthine oxidase (XO) inhibitory activity.

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Article Details

Year: 2014
Page: [207 - 210]
Pages: 4
DOI: 10.2174/15701808113109990056
Price: $65

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