Augmenting the Xanthine Oxidase Inhibitory Activity of Febuxostat by its Structural Modification
Kuruva Chandra Sekhar,
Katla Venkata Ramana,
CH. Rama Murthy,
Chamarthi Naga Raju.
The carboxamide derivatives of Febuxostat were synthesized via the reaction of Febuxostat with various
amines through by Schotten-Baumann reaction. All the synthesized compounds have been evaluated for their in vitro
Xanthine Oxidase inhibitory activity. The present study reveals that most of carboxamides were acting as better XO inhibitors
and play an important role in decreasing uricacid levels. Almost all the compounds surprisingly showed nearly
30% higher XO inhibition activities than the standard Allopurinol. 3h, 3k and 3l stand as the best among the synthesized
Keywords: Febuxostat carboxamide derivatives, Schotten-Baumann reaction, Xanthine oxidase (XO) inhibitory activity.
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