Salinomycin: A Novel Anti-Cancer Agent with Known Anti-Coccidial Activities

Author(s): Shuang Zhou, Fengfei Wang, Eric T. Wong, Ekokobe Fonkem, Tze-Chen Hsieh, Joseph M. Wu, Erxi Wu.

Journal Name: Current Medicinal Chemistry

Volume 20 , Issue 33 , 2013

Abstract:

Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Therefore, salinomycin may be considered as a promising novel anti-cancer agent despite its largely unknown mechanism of action.

This review summarizes the pharmacologic effects of salinomycin and presents possible mechanisms by which salinomycin exerts its anti-tumorigenic activities. Recent advances and potential complications that might limit the utilization of salinomycin as an anti-cancer and anti-CSC agent are also presented and discussed.

Keywords: Salinomycin, cancer stem cell, toxicity, drug.

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Article Details

VOLUME: 20
ISSUE: 33
Year: 2013
Page: [4095 - 4101]
Pages: 7
DOI: 10.2174/15672050113109990199
Price: $58

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