Current Bioinformatics

Yi-Ping Phoebe Chen
Department of Computer Science and Information Technology
La Trobe University
Melbourne
Australia

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Omics Derived Networks in Bacteria

Author(s): Aminael Sanchez-Rodriguez, Lore Cloots, Kathleen Marchal.

Abstract:

Understanding the cellular behavior from a systems perspective requires the identification of functional and physical interactions among diverse molecular entities in a cell (i.e. DNA/RNA, proteins and metabolites). Powerful and scalable technologies enabled the generation of genome-wide datasets that describe cellular systems by capturing the interactions of their building blocks under different environmental stimuli. The most straightforward way to represent such datasets is by means of molecular networks of which nodes correspond to molecular entities and edges to the interactions amongst those entities. In this review we give an overview of the different functional and physical interaction networks in bacteria that have been or potentially can be built by the integration of diverse omics datasets.

Keywords: Bacteria, dataintegration, molecular networks, network inference, omics data.

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Article Details

VOLUME: 8
ISSUE: 4
Year: 2013
Page: [489 - 495]
Pages: 7
DOI: 10.2174/1574893611308040011
Price: $58