The increased mortality rate for cardiovascular (CV) diseases in rheumatoid arthritis RA) patients has been
mainly attributed to an increased prevalence of some classical CV risk factors in these patients. Nonetheless, the potential
role of chronic inflammation itself as an independent CV risk factor has been recently emphasized. Indeed, different basic
alterations present in RA may anticipate and/or accelerate the atherosclerotic process in these patients. However, results of
clinical studies are conflicting. We therefore considered data of the more recently published meta-analyses aiming to perform
a critical reappraisal in such a topic. Unfortunately, there is a significant heterogeneity among the trials, and the role
of classical CV risk factors was not taken into account in several studies. Therefore, whether RA is an independent risk
for CV diseases still remains unclear.
Keywords: Rheumatoid arthritis, cardiovascular disease, meta-analysis, risk factors.
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