Current Rheumatology Reviews

Dr. Serena Guiducci  
Department of Biomedicine, Division of Rheumatology
University of Florence
Florence
Italy

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A Genopedia of Lupus Genes - Lessons from Gene Knockouts

Author(s): Yuyuan Guo, Jacob Orme, Chandra Mohan.

Abstract:

Systemic lupus erythematosus (SLE) is the quintessential complex, multifactorial systemic autoimmune disease. In particular, it is highly polygenic in origin in both humans and animal models. Mouse models of lupus help uncover the genetic and cellular etiologies of the disease, which often implicate homeostatic imbalances in specific cell types and pathways. This review compiles and explores the contributions of specific genes in genetically manipulated mouse models that develop lupus spontaneously. A current version of this compilation can be found on SLE BASE at http://www.mohanlab.org/SLE_BASE/gene.

Keywords: Systemic Lupus Erythematosus, genetic susceptibility, mouse models.

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2013
Page: [90 - 99]
Pages: 10
DOI: 10.2174/1573397111309020003
Price: $58