Microwave Assisted Synthesis and in vitro Antimicrobial Activities of Fluorine Containing 4-Benzofuran-2-yl-6-phenyl-pyrimidin-2-ylamines
Tejpal Singh Chundawat, Nutan Sharma and Sunita Bhagat
Pages 409-417 (9)
A series of new analogs fluorine containing heterocyclic system viz. 4-benzofuran-2-yl-6-phenyl-pyrimidin-2-
ylamine has been synthesized and evaluated for in vitro antibacterial and antifungal activities. Microwave assisted
Claisen-Schmidt condensation of 2-acetylbenzofuran (3) with fluorinated benzaldehydes (4) afforded corresponding
fluorinated chalcones (5a-g). The cyclocondensation of chalcones with guanidine hydrochloride in alkaline media under
microwave resulted in the formation of corresponding fluorine containing 4-benzofuran-2-yl-6-phenyl-pyrimidin-2-
ylamines (6a-g). All the synthesized compounds have been characterized on the basis of analytical and spectral data and
were screened for their antibacterial and antifungal activities. Some of the synthesized compounds showed good
antimicrobial activities against bacteria and fungi.
Claisen-Schmidt condensation, microwave assisted synthesis, benzofuran, pyrimidine, antimicrobial.
Organic Synthesis Research Laboratory, Department of Chemistry, A.R.S.D. College, University of Delhi, New Delhi-110021, India.