Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles Amicable for Automation

Author(s): Mitta Kavitha, Bodugam Mahipal, Prathama S. Mainkar, Srivari Chandrasekhar.

Journal Name: Combinatorial Chemistry & High Throughput Screening

Volume 16 , Issue 8 , 2013

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A three-component 3+2 cycloaddition reaction followed by Suzuki coupling reaction was carried out to synthesize a library of compounds using automation (parallel synthesizer). Scaffolds that are unexplored in literature were used for the synthesis of library. The iodo-triazoles formed by 3+2 cycloaddition reaction were coupled with boronic acids to get tri-substituted triazoles.

Keywords: Alkynes, azides, Suzuki reaction, Triazoles, [3+2]-cycloaddition.

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Article Details

Year: 2013
Page: [657 - 663]
Pages: 7
DOI: 10.2174/1386207311316080009
Price: $58

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