The present paper reports an easy preparation of imines of N-methyl-1H-indole-3-carboxaldehyde by its condensation
with alkyl and aromatic amines in ethanol without using any catalyst or dehydrating agent. The compounds
have been screened for their antibacterial, antifungal, crown gall tumor inhibitory, and cytotoxic activities. As a major
finding some of the compounds exhibited potential biological activity. The imine containing a 4-chlorophenyl group exhibits
potential antitumor activity and brine shrimp lethality against crown gall tumor and brine shrimps, respectively.
Furthermore, this imine containing a 4-chlorophenyl group also exhibits significant antifungal activity against Candida
albicans fungal strains. The compound containing N-diphenylmethyl group has been observed most active against the
Keywords: Antibacterial, antifungal, antitumor, cytotoxicity, Imines, N-Methyl-1H-indole.
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