Current Proteomics

Bernd Rehm  
Institute of Molecular BioSciences Massey University
Private Bag 11222
Palmerston North
New Zealand

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Clinical Proteomics in Cancer Research

Author(s): Elena Lopez, Luis Madero, Gustavo J. Melen, Manuel Ramirez, Dimitrios H. Roukos, William C. Cho.

Abstract:

Clinical proteomics studies are extensively being conducted in recent years. We have outlined some views about proteomics progresses for clinical research, via the understanding the molecular mechanisms of carcinogenesis, tumor response to therapy and biomarker identification versus novel therapeutic target-discovery; as well as proteomerelated methods used in cancer research. Integrative concepts of development of novel therapeutic targets and the application of proteomics in drug development are also discussed.

Several aspects are touched including the development of novel therapeutic targets, proteomics as a tool to discover biomarkers, discovery and validation of prognostic and predictive biomarkers, and biobanking versus proteomics.

Finally, we envision the application of clinical proteomics for future personalized cancer therapies can set up a consensus that will be reached amongst the scientific community.

Keywords: Cancer, clinical proteomics, personalized medicine, omics.

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Article Details

VOLUME: 10
ISSUE: 2
Year: 2013
Page: [179 - 191]
Pages: 13
DOI: 10.2174/15701646112099990001
Price: $58