How can Proteomics Reach Cancer Biomarkers?
Although proteomics is a very recently developed science, important advances have already occurred in this
field. There is growing interest in the scientific community for using this technology as a high-throughput innovative
strategy for biomarker discovery in the field of cancer research. However, certain challenges must be overcome before
reaching this goal. The basis for discovering reliable biomarkers is rooted in technical and biological parameters. The
main biological limit is outlining tumor heterogeneity, while methodological issues include appropriate study designs, the
use of sensitive technologies for screening, and the employment of confident strategies for data validation. This review
focuses on the major questions related to the strengths and limitations of the development of cancer biomarkers by proteomic-
Keywords: Biomarkers, cancer, design of studies, mass spectrometry, proteomics, tumor heterogeneity.
Rights & PermissionsPrintExport