Pluronic-based core/shell nanoparticles (NPs) were formed using various strategies such as self-assembly and
temperature induced-phase transition. To improve their functionality as a nanomedicine for diagnosis and therapy, the
vesicle fusion and layer by layer approach were employed. Because of the hydrophilic nature of the Pluronic shell and the
relatively small size, Pluronic-based core/shell NPs were used in order to improve their pharmacokinetic behaviors in
drugs and in imaging agents. This review will introduce various types of Pluronic-based core/shell NPs according to their
preparation method and formation mechanism. The focus will be on the Pluronic-based core/shell NPs for tumor targeting,
stimulated release of proteins, and cancer imaging capabilities.
Keywords: Antitumor efficacy, cancer targetability, chitosan/heparin composite, core/shell nanoparticles, enhanced permeability
and retention effect, layer-by-layer approach, molecular imaging agent, Pluornics, Pluronic/liposome composite nanoparticles,
polyethylene glycol, protein drug, self-assembly, temperature-induced phase transition, vesicle fusion.
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