Genistein Down-Regulates miR-223 Expression in Pancreatic Cancer Cells
Jia Ma, Long Cheng, Hao Liu, Jing Zhang, Ying Shi, Fanpeng Zeng, Lucio Miele, Fazlul H Sarkar, Jun Xia and Zhiwei Wang
Affiliation: Department of Biochemistry and Molecular Biology, Bengbu Medical College, Anhui, 233030, China.
Although genistein has been shown to inhibit tumorigenesis in a variety of human cancers including pancreatic
cancer (PC), the exact molecular mechanism of its anti-cancer effects has not yet been fully elucidated. Recently, microRNAs
(miRNAs) have been reported to regulate multiple aspects of tumor development and progression, indicating
that targeting miRNAs could be a novel strategy to treat human cancers. In the current study, we investigated whether a
natural compound genistein could down-regulate onco-miR-223, resulting in the inhibition of cell growth and invasion,
and induction of apoptosis in PC cells. We found that genistein treatment significantly inhibited miR-223 expression and
up-regulated Fbw7, one of the targets of miR-223. Moreover, down-regulation of miR-223 inhibited cell growth and induced
apoptosis in PC cells. These findings suggest that genistein exerts its anti-tumor activity partly through downregulation
of miR-223 in PC cells.
Keywords: miR-223, Fbw7, apoptosis, cell growth, genistein, pancreatic cancer.
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