Current Vascular Pharmacology

Dimitri P. Mikhailidis  
Academic Head, Deptartment of Clinical Biochemistry
Royal Free Hospital Campus
University College London Medical School
University College London (UCL)
Pond Street
London, NW3 2QG


The Pathophysiological Basis of Renal Nerve Ablation for the Treatment of Hypertension

Author(s): Ziakas A., Gossios T., Doumas M., Karali K., Megarisiotou A., Stiliadis I..


Renal sympathetic innervation plays an important role in blood pressure regulation. Gradual activation of renal sympathetic efferent nerves enhances renin release, promotes sodium and water re-absorption, and reduces renal blood flow and glomerular filtration rate. On the other hand, activation of renal afferent sympathetic nerves induced by renal injury results in central sympathetic activation. This reciprocal relationship between the kidneys and the brain is involved in the pathogenesis of hypertension and other disease conditions characterized by sympathetic overactivity. Renal sympathetic nerve ablation has been recently introduced for the treatment of resistant hypertension. This review aims to provide the pathophysiological basis of renal nerve ablation for the attenuation of sympathetic overactivity.

Keywords: Renal nerve ablation, renal sympathetic denervation, anatomy, physiology, efferent renal sympathetic nerves, afferent renal sympathetic nerves, renin, sodium reabsorption, renal blood flow, glomerular filtration rate.

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Article Details

Year: 2014
Page: [23 - 29]
Pages: 7
DOI: 10.2174/15701611113119990145