Topics in Anti-Cancer Research

Volume: 2

Indexed in: Accepted Book Citation Index, Science (BKCI-S), Chemical Abstracts, BIOSIS Previews, EBSCO, Ulrich's Periodicals Directory.

This is the second volume of the Patent eBook Series titled Topics in Anti-Cancer Research. The eBook includes updated chapters on topics relevant to contemporary cancer research published in the ...
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Enhancing the Anticancer Activity of Erlotinib in Glioblastoma

Pp. 407-436 (30)

Georg Karpel-Massler, Christian R. Wirtz and Marc-Eric Halatsch

Abstract

Glioblastoma multiforme (GBM) is the most common malignant intrinsic brain tumor in adults. Especially in this disease, qualitative and quantitative aspects render the dysregulated epidermal growth factor receptor (HER1/EGFR) an outstanding therapeutic target. A variety of therapeutic compounds was developed to target HER1/EGFR among which the clinically most advanced agents are small molecule tyrosine kinase (TK) inhibitors. Unfortunately, clinical studies examining their therapeutic efficacy have so far failed to document a major therapeutic break-through in the setting of GBM. Thus, the targeted approach against HER1/EGFR likely requires a synergistic drug combination strategy to ultimately become successful in this disease. This patents chapter focuses on innovative therapeutic strategies combining HER1/EGFR-targeted TK inhibitors with novel agents which for the most part have not been evaluated for the treatment of GBM yet but which constitute interesting candidates for further evaluation in this setting.

Keywords:

Angiogenesis, combination therapy, erlotinib, glioblastoma, HER1/EGFR, high-grade glioma, histone deacetylase inhibitors, IGF1R, Kit, multi-targeting, neurooncology, oncogene, pralatrexate, radiotherapy, romidepsin, targeted therapy, temozolomide, tumorigenesis, tyrosine kinase inhibitor, vascular disrupting agents.

Affiliation:

Department of Neurosurgery, University of Ulm School of Medicine, Albert-Einstein-Allee 23, D-89081 Ulm, Germany.