Topics in Anti-Cancer Research

Volume: 2

Indexed in: Accepted Book Citation Index, Science (BKCI-S), Chemical Abstracts, BIOSIS Previews, EBSCO, Ulrich's Periodicals Directory.

This is the second volume of the Patent eBook Series titled Topics in Anti-Cancer Research. The eBook includes updated chapters on topics relevant to contemporary cancer research published in the ...
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Angiogenesis: Therapeutic Target in Renal Cell Carcinoma

Pp. 279-298 (20)

Manisha Singh, Sudip Nanda, Santo Longo and Shree G. Sharma

Abstract

Renal cell carcinoma (RCC) is one of the most common cancers in the United States. Recent achievements in translational research have led to significant developments in treatment strategies for this malignancy. RCC is a richly vascular neoplasm. A better understanding of disease biology has helped in the development of anti-angiogenic therapy. Vascular endothelial growth factor (VEGF) is the most important molecular target in the treatment of RCC. Patents have been filed for anti- VEGF and other molecular pathways involved in the pathogenesis of RCC. This chapter provides an overview of angiogenesis in RCC, important anti-angiogenic drugs for treating RCC and some developmental drugs and patents which might shape the treatment of RCC in future.

Keywords:

Angiogenesis, antiangiogenic therapy, axitinib, bevacizumab, mTOR, patents, pazopanib, renal cell carcinoma, sorafenib, sunitinib, temsirolimus, VEGF, VHL.

Affiliation:

Department of Pathology, University of Arkansas for Medical Sciences, 4301 West Markham # 517, Little Rock, Ar, 72205, USA.