L-Proline is a cheap, water-soluble organocatalyst that is able to induce the synthesis of a large number of heterocyclic systems.
This work is reviewed, with emphasis on the literature of the 2005-2011 period. The domino reactions have been classified according
to the nature of the first step of their proposed mechanisms, as follows: (i) iminium-initiated domino mechanisms; (ii) enamineinitiated
domino mechanisms; (iii) reactions proceeding via the intermediacy of dienamines; (iv) reactions in which proline acts as a
Lewis base and (v) L-proline/metal catalysed reactions.
Keywords: L-proline, organocatalyst, multicomponent, domino, synthesis, heterocycles.
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