A series of N-protected non-proteinogenic α-amino acid esters have been prepared. The key step in this synthesis is the treatment
of trichloroacetimidate 3, 8 or acetate 4, 9 derivatives with Lewis acid and C-active nucleophiles to afford the desired products via
C-C bond formation and the introduction of substituents at the α-position of the amino acid in good yields and short reaction time.
Keywords: Non-proteinogenic amino acids, Trichloroacetimidate coupling method, Acetate coupling method, C-C bond formation, Cnucleophiles.
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