An account of our development of the Pot, Atom and Step Economic (PASE) synthesis of tetrahydropyrans, dihydropyrans
and piperidines, based on the Maitland-Japp reaction is given. The value of these reactions as a strategy in natural product synthesis is
highlighted and recent further developments of the PASE syntheses in the literature is reported.
Keywords: Dihydropyrans, Multi-component, PASE, Piperidines, Tetrahydropyrans.
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