Spiroheterocyclic ring systems are attractive synthetic targets due to their interesting conformational features and their structural
implications on their activity in biological systems. Consequently, a vast deal of research by synthetic organic as well as medicinal
chemists pertains to the synthesis of these heterocycles employing diverse synthetic methodologies. Among them, one-pot multicomponent
1,3-cycloaddition reactions have emerged as preferred synthetic protocol in view of their convergence, atom economy, ecofriendliness,
flexibility and facile automation. This review article focuses on the assembly of mono-, di- and multispiro heterocyclic hybrids
via aforesaid synthetic methodologies with a variety of dipolarophiles.
Keywords: Multicomponent, 1, 3-Dipolar cycloadditions, Spiroheterocycles, Azomethine ylides and Nitrile oxides.
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