Michael Addition-initiated Sequential Reactions from 1,3-dicarbonyls for the Synthesis of Polycyclic Heterocycles

Author(s): Xavier Bugaut, Damien Bonne, Yoann Coquerel, Jean Rodriguez, Thierry Constantieux.

Journal Name: Current Organic Chemistry

Volume 17 , Issue 18 , 2013

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Abstract:

This review aims to highlight the most significant recent developments on synthetic strategies involving consecutive, domino and multicomponent reactions featuring a Michael addition-initiating step for the synthesis of polycyclic heterocycles from 1,3- dicarbonyls. These original sequences constitute more efficient and eco-compatible alternatives to known synthetic approaches to heterocyclic compounds allowing for an even faster and highly desirable generation of molecular diversity and complexity.

Keywords: Consecutive reactions, Domino reactions, Multicomponent reactions, Michael addition, Polycyclic heterocycles, 1, 3-Dicarbonyl compounds.

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Article Details

VOLUME: 17
ISSUE: 18
Year: 2013
Page: [1920 - 1928]
Pages: 9
DOI: 10.2174/13852728113179990090

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