Current Biotechnology

Pabulo Henrique Rampelotto  
Center of Biotechnology and PPGBCM
Federal University of Rio Grande do Sul
Porto Alegre, RS
Brazil

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Osteocyte biology and space flight

Author(s): Paola Divieti Pajevic, Jordan M Spatz, Jenna Garr, Chris Adamson, Lowell Misener.

Abstract:

The last decade has seen an impressive expansion of our understanding of the role of osteocytes in skeletal homeostasis. These amazing cells, deeply embedded into the mineralized matrix, are the key regulators of bone homeostasis and skeletal mechano-sensation and transduction. They are the cells that can sense mechanical forces applied to the bone and then translate these forces into biological responses. They are also ideally positioned to detect and respond to hormonal stimuli and to coordinate the function of osteoblasts and osteoclasts through the production and secretion of molecules such as Sclerostin and RANKL. How osteocytes perceive mechanical forces and translate them into biological responses in still an active area of investigation. Novel “in vitro” models as well the opportunity to study these cells under microgravity condition, will allow a closer look at the molecular and cellular mechanisms of mechano-transduction. This article highlights investigations on osteocytes and discusses their significance in our understanding of skeletal mechano-transduction.

Keywords: Osteocytes, mechano-transduction and microgravity.

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Article Details

VOLUME: 2
ISSUE: 3
Year: 2013
Page: [179 - 183]
Pages: 5
DOI: 10.2174/22115501113029990017
Price: $58