Abstract
Presented work focuses on the response of osteogenic, osteoblastic and mesenchymal stem cells to real and simulated microgravity. Mesenchymal stem cells are the residents of adult bone marrow stroma. These cells are capable of differentiating towards osteogenic, adipogenic and chondrogenic lineages. The advantage of using MSCs in space-related research is that these cells are relevant tool to develop bone tissue. Osteogenic potential of MSCs allows investigating osteogenesis from the most uncommitted cells while still maintaining all main characteristics of bone differentiation (osteogenic gene expression, osteogenic markers, matrix maturation and mineralization). Recent studies have demonstrated that MSCs are targeted by microgravity and accordingly can be involved in space flight-induced osteopenia. These findings determine the necessity of further study of human MSC biology in real and simulated microgravity conditions.
Keywords: Microgravity, osteopenia, osteoblasts, mesenchymal stem cells, RPM.
Current Biotechnology
Title:Microgravity and Mesenchymal Stem Cell Response
Volume: 2 Issue: 3
Author(s): L.B. Buravkova, P.M. Gershovich, J.G. Gershovich and A.I. Grigoriev
Affiliation:
Keywords: Microgravity, osteopenia, osteoblasts, mesenchymal stem cells, RPM.
Abstract: Presented work focuses on the response of osteogenic, osteoblastic and mesenchymal stem cells to real and simulated microgravity. Mesenchymal stem cells are the residents of adult bone marrow stroma. These cells are capable of differentiating towards osteogenic, adipogenic and chondrogenic lineages. The advantage of using MSCs in space-related research is that these cells are relevant tool to develop bone tissue. Osteogenic potential of MSCs allows investigating osteogenesis from the most uncommitted cells while still maintaining all main characteristics of bone differentiation (osteogenic gene expression, osteogenic markers, matrix maturation and mineralization). Recent studies have demonstrated that MSCs are targeted by microgravity and accordingly can be involved in space flight-induced osteopenia. These findings determine the necessity of further study of human MSC biology in real and simulated microgravity conditions.
Export Options
About this article
Cite this article as:
Buravkova L.B., Gershovich P.M., Gershovich J.G. and Grigoriev A.I., Microgravity and Mesenchymal Stem Cell Response, Current Biotechnology 2013; 2 (3) . https://dx.doi.org/10.2174/22115501113029990016
DOI https://dx.doi.org/10.2174/22115501113029990016 |
Print ISSN 2211-5501 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-551X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Mucoadhesive Low Molecular Chitosan Complexes to Protect rHuKGF from Proteolysis: <i>In-vitro</i> Characterization and FHs 74 Int Cell Proliferation Studies
Current Pharmaceutical Biotechnology Progress Toward Understanding the Nature and Function of C-H...O Interactions
Current Organic Chemistry Development of Anti-CD20 Antigen-Targeting Therapies for B-cell Lymphoproliferative Malignancies - The State of the Art
Current Drug Targets Carcinogenesis and Therapeutic Strategies in Thyroid Cancer
Current Drug Targets Effects of PHA-665752 and Cetuximab Combination Treatment on In Vitro and Murine Xenograft Growth of Human Colorectal Cancer Cells with KRAS or BRAF Mutations
Current Cancer Drug Targets Risk of Bleeding Related to Antithrombotic Treatment in Cardiovascular Disease
Current Pharmaceutical Design Anti-platelet Drug-loaded Targeted Technologies for the Effective Treatment of Atherothrombosis
Current Drug Targets Long-term Potentiation at Spinal C-fiber Synapses: A Target for Pathological Pain
Current Pharmaceutical Design Selected Phytochemicals to Combat Lungs Injury: Natural Care
Combinatorial Chemistry & High Throughput Screening Targeting Kynurenine 3-Monooxygenase (KMO): Implications for Therapy in Huntingtons Disease
CNS & Neurological Disorders - Drug Targets Organotypic Cultures as Tool to Test Long-Term Effects of Chemicals on the Nervous System
Current Medicinal Chemistry Assessment of Signal Peptides to Optimize Interleukin 2 (IL-2) Folding and Expression
Current Proteomics Matrix Metalloproteinase Dependent Cleavage of Cell Adhesion Molecules in the Pathogenesis of CNS Dysfunction with HIV and Methamphetamine
Current HIV Research Heat Shock Protein 90 Inhibitors as Broad Spectrum Anti-Infectives
Current Pharmaceutical Design Neuroprotective Effects of <i>Nardostachys jatamansi</i> Against BSO Induced Anxiety via its Antioxidant Machinery and by Elevating Catecholamines and GABA levels in Mice
Current Traditional Medicine Osteoprotegerin Positively Regulates Hematopoietic Progenitor Cells
Current Stem Cell Research & Therapy A Review on the Current Methods of Chinese Hamster Ovary (CHO) Cells Cultivation for the Production of Therapeutic Protein
Current Drug Discovery Technologies Enhancing Aqueous Solubility of Ketoprofen by Fusion Technique Using Suitable Co-formers
Current Drug Therapy Rexinoids for Prevention and Treatment of Cancer: Opportunities and Challenges
Current Topics in Medicinal Chemistry Oxidative stress and Parkinson’s disease: New hopes in treatment with herbal antioxidants
Current Pharmaceutical Design