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Current Bioactive Compounds
ISSN (Print): 1573-4072
ISSN (Online): 1875-6646
VOLUME: 9
ISSUE: 3
DOI: 10.2174/15734072113099990014      Price:  $58









An Efficient and Environmentally Benign Four-component Domino Protocol for Synthesis of Spirooxindoles Spiroannulated with Fused Heterosystems of Privileged Heterocycles

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Author(s): Sarita Khandelwal, Anshu Rajawat and Mahendra Kumar
Pages 203-210 (8)
Abstract:
An efficient and environmentally benign one- pot four-component domino protocol has been presented for the synthesis of structurally diverse spirooxindoles spiroannulated with chromenopyrazolophthalazines, indazolophthalazines and pyranopyrazolophthalazines involving the reaction of phthalic anhydride, hydrazine hydrate, isatins and cyclic ketones in aqueous alcoholic medium (H2O-C2H5OH: v 5:1) using catalytic amount of sulphamic acid.
Keywords:
Chromenopyrazolophthalazines, indazolophthalazines, multicomponent reactions, pyranopyrazolophthalazines, spiroheterocycles, spirooxindoles.
Affiliation:
Department of Chemistry, University of Rajasthan, Jaipur, 302004, India.