An Efficient and Environmentally Benign Four-component Domino Protocol for Synthesis of Spirooxindoles Spiroannulated with Fused Heterosystems of Privileged Heterocycles

Author(s): Sarita Khandelwal, Anshu Rajawat, Mahendra Kumar.

Journal Name:Current Bioactive Compounds

Volume 9 , Issue 3 , 2013


An efficient and environmentally benign one- pot four-component domino protocol has been presented for the synthesis of structurally diverse spirooxindoles spiroannulated with chromenopyrazolophthalazines, indazolophthalazines and pyranopyrazolophthalazines involving the reaction of phthalic anhydride, hydrazine hydrate, isatins and cyclic ketones in aqueous alcoholic medium (H2O-C2H5OH: v 5:1) using catalytic amount of sulphamic acid.

Keywords: Chromenopyrazolophthalazines, indazolophthalazines, multicomponent reactions, pyranopyrazolophthalazines, spiroheterocycles, spirooxindoles.

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Article Details

Year: 2013
Page: [203 - 210]
Pages: 8
DOI: 10.2174/15734072113099990014
Price: $58