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Current Bioactive Compounds
ISSN (Print): 1573-4072
ISSN (Online): 1875-6646
VOLUME: 9
ISSUE: 3
DOI: 10.2174/15734072113099990013      Price:  $58









Quassinoids from Brucea Javanica Seeds Inhibiting the Replication of Tobacco Mosaic Virus

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Author(s): Zheng-Kun Zhang, Ming-An Ouyang, Jia-Sui Zhan and Zu-Jian Wu
Pages 247-254 (8)
Abstract:
Active quassinoids extracted from Brucea javanica seeds were tested for their activities against Tobacco mosaic virus (TMV). Results from activity-guided assays indicated that the compounds can reduce the replication of the virus by up to 98.5% (50 µg/mL). The active quassinoids inhibit the replication of TMV genomic and subgenomic RNAs and the synthesis of TMV coat protein in vivo but did not destroy the integrality of the virus. Structure-activity relationship (SAR) analysis indicated that the positions of the furan ring, the α,β-conjugated ketone, and integrity of the A ring had significant impacts on the antiviral activity of quassinoids.
Keywords:
Simaroubaceae, Brucea javanica, quassinoids, inhibition, TMV, SAR.
Affiliation:
Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, P. R. China.